Jurnal Ilmiah Kimia Molekul

Choiri et al., Syaiful (2020) Jurnal Ilmiah Kimia Molekul. Molekul, 15 (1). pp. 1-62. ISSN 2503-0310

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Multicomponent crystal (MCC) formulation consists of drug and co-former that spectrophotometrically has an interference each other. The aim of this research was to evaluate and develop the analytical method to obtain a fast, cheap,efficient, and adequate method to estimate desloratadine (DES) in MCC formulation using three different methods. Single wavelength calibration model was constructed at 290 nm, multiple component equations was obtained from 273 nm and 283 nm, and multivariate analysis consists of partial least square (PLS) and principal component analysis (PCA), a chemometric based, assisted the model selection and model calibration. Single wavelength method and multivariate analysis model had been fully validated i.e. range, specificity, accuracy, precision, limit of detection, and limit of quantification. A multivariate analysis had more adequate ability to estimate the DES and co-former in the MCC formulation.

Item Type: Article
Uncontrolled Keywords: Desloratadine, multicomponent crystal, multivariate, PLS
Subjects: R Medicine > R Medicine (General)
Depositing User: Stikes Borneo Cendekia Medika
Date Deposited: 20 Oct 2020 13:26
Last Modified: 02 Nov 2020 04:16
URI: http://repository.stikesbcm.ac.id/id/eprint/55

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