Journal of Clinical Tuberculosis and Other Mycobacterial Diseases

Abudaf, Naief N. (2018) Journal of Clinical Tuberculosis and Other Mycobacterial Diseases. Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 10 (1). pp. 1-32. ISSN 2405-5794

[img] Text
vol 10 no 1 2018.pdf - Published Version
Restricted to Repository staff only

Download (2MB)
[img] Text
vol 11 no 1 2018.pdf - Published Version
Restricted to Repository staff only

Download (4MB)
[img] Text
vol 12 no 2018.pdf - Published Version
Restricted to Repository staff only

Download (11MB)
[img] Text
vol 13 no 1 2018.pdf - Published Version
Restricted to Repository staff only

Download (2MB)

Abstract

Nontuberculous mycobacteria (NTM) are, by definition, mycobacteria unrelated to the Mycobacterium tuberculosis complex and Mycobacterium leprae. NTM are an ineluctable part of the natural environment. Isolates of NTM have been recovered from soil, surface and tap water, animals and even food products [1,2]. More than 170 species of NTM have been described in the literature [3]. The Mycobacterium terrae complex (MTC) is a group of environmental mycobacteria most commonly implicated as causative agents in bone and joint infections arising from direct environmental inoculation injuries [4]. Prior to the introduction of more sophisticated means of species identification, the MTC was initially identified phenotypically and comprised of nonchromogenic, slowly-growing species – M. terrae, and M. nonchromogenicum [5]. The advent of gene sequencing leads to further delineation and new species recognition within the MTC. Currently, the MTC has expanded to include other genetically similar mycobacteria: M. kumamotonense [6], M. senuense [7], M. paraterrae [8], Mycobacterium strain JDM601 [9], M. engbaekii [10], M. longobardum [10],M. heraklionense [10], M. virginiense [4], and M. arupense [11].Since its first isolation in 2006 by Cloud et al., at least ten clinical reports (Table 1) of M. arupense and numerous more reports on its isolation from environmental and clinical samples have been reported in the English literature. In a 2016 study by Vasireddy et al., 26 clinical isolates associated with tenosynovitis or osteomyelitis from 1984 to 2014, previously diagnosed by nonmolecular methods as M. terrae and M. nonchromogenicum, underwent molecular genetic testing by 16S ribosomal RNA (16S rRNA), heat-shock protein 65 (hsp65), and RNA polymerase subunit B (rpoB) sequencing [4]. In this report, 10 of the mycobacteria were now identified as M. arupense. The authors also evaluated 14 previously published cases of tenosynovitis due to MTC based on DNA sequencing, and identified 4 of these as a 100% identity with M. arupense type strain, and an additional 4 with greatest identity with M. arupense type strain. These findings highlight the need for species identification using gene sequencing methods, and suggests that a significant portion of previously MTC related infections diagnosed by culture and phenotypic means could be now classified as possible M. arupense.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: Stikes Borneo Cendekia Medika
Date Deposited: 23 Oct 2020 13:27
Last Modified: 02 Nov 2020 03:36
URI: http://repository.stikesbcm.ac.id/id/eprint/87

Actions (login required)

View Item View Item